NEW YORK (AP) — Stocks that moved substantially or traded heavily Thursday on the New York Stock Exchange and Nasdaq Stock Market:

NYSE

Barclays PLC, down $1.49 at $10.84

U.S.-traded shares of the British bank tumbled after it was fined $453 million for manipulating a key interest rate between 2005 and 2009.

HCA Holdings Inc., up $2.86 at $29.47

The Supreme Court upheld President Barack Obama's health care overhaul, which may lead to more insured people visiting hospitals.

WellPoint Inc., down $3.59 at $65.90

The insurer's shares fell after the health-care ruling, but a Jefferies analyst said insurance companies would benefit in the long run.

Tenet Healthcare Corp., up 27 cents at $5.25

Another company seen as benefiting from the health care overhaul, which may lead to more hospital visits.

Amerigroup Corp., up $3.07 at $65.47

Much of the insurer's business is focused on publicly funded health care like Medicaid, which is expected to expand under the health care overhaul.

JPMorgan Chase & Co., down 90 cents at $35.88

The New York Times reported that the bank's trading loss could reach $9 billion, much larger than the bank has acknowledged.

Nasdaq

Anthera Pharmaceuticals Inc., down $1.94 at 81 cents

The company said its experimental lupus treatment blisibimod failed in a clinical trial, and that it has changed its development plans for the drug.

Orexigen Therapeutics Inc., up 98 cents at $5.90

The FDA approved a competitor's anti-obesity drug, which some see as an indication that an approval for Orexigen's drug is more likely.